Open AccessUpregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo
Author(s) -
Salma Abdi Mahmoud,
Mohammed Ibrahim Mohammed,
Muhiddin Abdi Mahmoud,
Adam Munkaila,
Iddrisu Baba Yabasin
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_194_17
Subject(s) - downregulation and upregulation , in vivo , flow cytometry , cell growth , microbiology and biotechnology , chemistry , western blot , biology , cancer research , biochemistry , gene
Sulfatase-1 (SULF-1) is one of the genes associated with the inhibition of several signaling pathways by desulfating HSPG in cancer cells. The aim of this study is to investigate the effect of SULF-1 upregulation on SKOV3 ovarian cancer cell line and its influence on cell proliferation, migration, invasion in vitro, and lymph node metastasis in 615 inbred mice in vivo.