Open AccessPlasma miR-183-5p in colorectal cancer patients as potential predictive lymph node metastasis marker
Author(s) -
Reza Negarandeh,
Fatemeh Sanjabi,
Abolfazl Akbari,
Ramazan Mirzaei,
Azam Fattahi
Publication year - 2022
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_174_20
Subject(s) - medicine , colorectal cancer , biomarker , stage (stratigraphy) , oncology , clinical significance , oncogene , lymph node , adjuvant therapy , cancer , metastasis , predictive marker , distant metastasis , lymph node metastasis , gastroenterology , cell cycle , biology , paleontology , biochemistry
Lymph node metastasis (LNM) is a point that often, treatment is not effective in colorectal cancer (CRC). Clinical and pathologic markers of prognosis help clinicians in selecting patients for adjuvant therapy after surgical resection in CRC. MiR-183-5p has been demonstrated to play as an oncogene in CRC, although its biological role still remains unclear. The aim of this study was to evaluate the expression of miR-183-5p in CRC and its potential relevance to clinicopathological characteristics as a prognostic biomarker.