Open AccessA study of natural IgG antibodies against ATP-binding cassette subfamily C member 3 in oral squamous cell carcinoma
Author(s) -
Xiu Liu,
Zhicheng Huang,
He Zhang,
Qingyong Meng,
Xiaoyu Wang,
Ying Hu
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_150_18
Subject(s) - antibody , flow cytometry , microbiology and biotechnology , biology , cell growth , apoptosis , cell culture , cell cycle , cell , cancer research , chemistry , immunology , biochemistry , genetics
ATP-binding cassette subfamily C member 3 (ABCC3) is involved in multidrug resistance and is overexpressed in some solid tumors. Recent work revealed an increase in circulating anti-ABCC3 antibodies in lung and esophageal cancers. This in vitro study was undertaken to investigate the effects of the natural IgG antibody against the ABCC3-derived peptide antigen on proliferation of oral squamous cell carcinoma (OSCC) cells and augment the development of efficient and effective treatments in patients with OSCC.