Open AccessMicrofilariae in bone marrow aspirate of a case of myelofibrosis: A cause or coincidence?
Author(s) -
Khaliqur Rahman,
Shivangi Harankhedkar,
Ruchi Gupta,
Tanvi Gupta,
Seema Sharma,
Soniya Nityanand
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_1413_16
Subject(s) - microfilaria , leukocytosis , wuchereria bancrofti , pathology , myelofibrosis , medicine , bone marrow , myeloproliferative neoplasm , basophilia , monocytosis , asymptomatic , filariasis , immunology , helminths
Filariasis is among the common parasitic infestations found in India, with Wuchereria bancrofti being the most common causative organism. Presentation ranges from clinically asymptomatic to profound elephantiasis. It is also detected incidentally in diagnostic samples such as body fluids, fine needle aspirates, peripheral blood smears, and other cytological smears. Its detection in bone marrow aspirates with an associated hematolymphoid neoplasm is rare, with only a few case reports. We report one such case of young male who presented with leukocytosis of 253 × 10 9 /L with basophilia and massive splenomegaly. Bone marrow aspirate smears showed the presence of microfilariae along with other features of a myeloproliferative neoplasm (MPN). The present case is probably the first case of finding a microfilaria in a case of MPN.