Open AccessExpression and significance of Twist, estrogen receptor, and E-cadherin in human breast cancer cells and tissues
Author(s) -
Ruizhi Tan,
Li Wang,
Jie Song,
Jianchun Li,
Tao He
Publication year - 2017
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_1396_16
Subject(s) - metastasis , twist transcription factor , estrogen receptor , cancer research , breast cancer , immunohistochemistry , cadherin , biology , cancer , pathology , medicine , epithelial–mesenchymal transition , cell , genetics
Breast cancer is one of the most common malignancies in women, and the tumor cells' invasion and metastasis is the main cause of death. Recent reports showed that Twist, a transcription factor, plays multiple roles in breast cancer initiation, progress, and metastasis. However, the underlying mechanisms of Twist in tumor invasion and metastasis of breast cancer still remain unclear. Here, we examined the correlation between Twist, E-cadherin, and estrogen receptor (ER) in promoting invasion and metastasis in breast cancer cells and tissues.