Open AccessComparison of different stains in exfoliated oral mucosal cell micronucleus of potentially malignant disorders of oral cavity
Author(s) -
Jagriti Gupta,
Kumkum Gupta,
Rahul Agarwal
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_1326_16
Subject(s) - micronucleus test , giemsa stain , oral submucous fibrosis , medicine , papanicolaou stain , staining , micronucleus , pathology , oral cavity , leukoplakia , cytology , buccal administration , exfoliative cytology , dermatology , gastroenterology , cancer , cervical cancer , dentistry , toxicity
Micronucleus (MN) has been proved to be an important biomarker of genomic damage. Leishman Giemsa (LG) cocktail, being a relatively new staining technique, has not been used in exfoliative cytology. The aim of this study is to observe and compare the micronuclei (MN) frequency in potentially malignant disorders (PMDs) and also to compare the staining efficacy of May-Grünwald Giemsa (MGG), LG cocktail, and Papanicolaou (PAP) for micronuclei in exfoliated oral mucosal cells.