Open AccessInsufficient radiofrequency ablation promotes epithelial–mesenchymal transition mediated by interleukin-6/signal transducer and activator of transcription 3/Snail pathway in the H22 cells
Author(s) -
Tong Zhou,
Bin Liu,
Yongzheng Wang,
Wujie Wang,
Haiyang Chang,
Dong Liu,
Yuliang Li,
Zhaomin Song
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_12_20
Subject(s) - epithelial–mesenchymal transition , vimentin , stat protein , stat3 , snail , cancer research , in vivo , ablation , biology , chemistry , microbiology and biotechnology , downregulation and upregulation , phosphorylation , medicine , immunohistochemistry , immunology , biochemistry , ecology , gene
Radiofrequency ablation (RFA), an established and minimally invasive therapy for hepatocellular carcinoma, has become an important treatment strategy. However, tumor aggressiveness remains a common problem. The epithelial-mesenchymal transition (EMT) is thought to play an important role in this process.