Open AccessSerum miR-20a and miR-486 are potential biomarkers for discriminating colorectal neoplasia: A pilot study
Author(s) -
Qinglan Yang,
Shuiming Wang,
Jianfeng Huang,
Chengwan Xia,
Heiying Jin,
Yida Fan
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_1198_16
Subject(s) - medicine , microrna , colorectal cancer , receiver operating characteristic , oncology , gastroenterology , real time polymerase chain reaction , cancer , biology , gene , biochemistry
Recent advances in circulating microRNAs (miRNAs) as noninvasive biomarkers have provided promising prospect in detecting colorectal cancer (CRC). However, the capability of miRNAs for detecting colorectal neoplasia (CRN, including precancerous lesions and curable stage CRCs) remains unclear. This study aimed to identify the potential of serum miRNAs (miR-20a, miR-486, miR-92a, and miR-135b) selected from the literature for discriminating CRN patients.