Open AccessSomatic mitochondrial DNA D-loop mutations in meningioma discovered: A preliminary data
Author(s) -
Abdul Aziz Mohamed Yusoff,
Siti Zulaikha Nashwa Mohd Khair,
Wan Salihah Wan Abdullah,
Siti Muslihah Abd Radzak,
Jafri Malin Abdullah
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_1132_16
Subject(s) - mitochondrial dna , hypervariable region , biology , d loop , mtdna control region , meningioma , somatic cell , genetics , mutation , polymerase chain reaction , microbiology and biotechnology , dna sequencing , germline mutation , dna , gene , pathology , medicine , haplotype , genotype
Meningiomas are among the most common intracranial tumors of the central nervous system. It is widely accepted that the initiation and progression of meningiomas involve the accumulation of nucleus genetic alterations, but little is known about the implication of mitochondrial genomic alterations during development of these tumors. The human mitochondrial DNA (mtDNA) contains a short hypervariable, noncoding displacement loop control region known as the D-Loop. Alterations in the mtDNA D-loop have been reported to occur in most types of human cancers. The purpose of this study was to assess the mtDNA D-loop mutations in Malaysian meningioma patients.