Open AccessTherapeutic effects of oleuropein on cisplatin-induced pancreas injury in rats
Author(s) -
Murat Bakır,
Fatime Geyikoğlu,
Kübra Koç,
Salim Çeriğ
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_1040_16
Subject(s) - malondialdehyde , oxidative stress , pancreas , histopathology , antioxidant , toxicity , h&e stain , amylase , cisplatin , lipase , medicine , necrosis , chemistry , pharmacology , endocrinology , pathology , immunohistochemistry , biochemistry , enzyme , chemotherapy
Cisplatin (CIS) is an influential chemotherapeutic agent in the treatment of several types of malignant solid tumors, but its clinical use is related with ototoxicity. Oleuropein (OLE) is a natural antioxidant and scavenging free radicals. Here, we first explore the efficacy of OLE in pancreas against to the toxicity of CIS and also analyses its mechanism.