Open AccessEvaluation of Aloe vera as matrix metalloproteinase inhibitor in human dentin with and without dentin-bonding agent: An in vitro study
Author(s) -
Sarita Bhandari,
RonyT Kondody,
ArathiS Nair,
Rhea Mathew,
K P Divakar,
Manjusha Nambiar
Publication year - 2021
Publication title -
journal of conservative dentistry/journal of conservative dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 31
eISSN - 0974-5203
pISSN - 0972-0707
DOI - 10.4103/jcd.jcd_474_21
Subject(s) - dentin , aloe vera , matrix metalloproteinase , adhesive , chemistry , pulp (tooth) , materials science , dentistry , biochemistry , composite material , layer (electronics) , traditional medicine , medicine
Proper hybrid layer formation lays the foundation of resin-dentin bonding. The resin infiltration in demineralized dentin collagen couples with the adhesive/resin composites in the mineralized dentin surface. However, the activation of enzymatic activity in the collagen matrix can degrade the hybrid layer. Over the time, it leads to reduced bond strength. Mainly, the enzymes involved are matrix metalloproteinases (MMPs) which are involved in degrading most of the extracellular matrix components. Aloe vera is an herb with an anti-inflammatory effect, but its role in human dentin as an enzyme inhibitor has not been verified yet.