Open AccessEffect of Tribulus terrestris in mercuric chloride-induced renal accumulation of mercury and nephrotoxicity in rat
Author(s) -
Harlokesh Narayan Yadav,
Uma Sharma,
Sanjay Singh,
Yogendra Kumar Gupta
Publication year - 2019
Publication title -
journal of advanced pharmaceutical technology and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
eISSN - 2231-4040
pISSN - 0976-2094
DOI - 10.4103/japtr.japtr_386_18
Subject(s) - nephrotoxicity , chemistry , malondialdehyde , oxidative stress , glutathione peroxidase , kidney , blood urea nitrogen , mercury (programming language) , creatinine , pharmacology , antioxidant , glutathione , superoxide dismutase , tribulus terrestris , medicine , endocrinology , biochemistry , pathology , enzyme , alternative medicine , traditional chinese medicine , computer science , programming language
Mercury generates free radicals and subsequently increases oxidative stress, which leads to renal injury. Tribulus terrestris (TT) has good anti-inflammatory and antioxidant properties. Hydroalcoholic extract of different dose of TT was evaluated against mercuric chloride-induced nephrotoxicity. Rats ( n = 6) were treated with TT at doses of 100, 200, and 300 mg/kg. Drugs were administered orally for 7 days. Single dose of mercuric chloride (5 mg/kg, intraperitoneal) on the 5 th day caused significant elevation of blood urea nitrogen, serum creatinine, malondialdehyde, liver fatty acid binding protein, kidney injury molecule-1, and kidney mercury level and fall in glutathione, superoxide dismutase, glutathione peroxidase, and histopathological changes in disease control as compared to normal control group ( P < 0.001). Dose of TT 200 and 300 mg/kg significantly ( P < 0.001) prevented the renal injury, and mercury accumulation in kidney tissues significantly decreases in higher dose, i.e., 300 mg/kg as compared to control group. Our result indicates that the treatment of TT exerted significant protection against renal damage induced by mercuric chloride possibly due to its antioxidant and anti-inflammatory properties and by decreasing the renal accumulation of mercury.