Open AccessPolymeric worm-like nanomicellar system for accelerated wound healing
Author(s) -
Aarti Singh,
Adeeba Shakeel,
Dakshi Kochhar,
Sampathkumar Jeevanandham,
Satyendra Kumar Rajput,
Monalisa Mukherjee
Publication year - 2020
Publication title -
journal of advanced pharmaceutical technology and research
Language(s) - Danish
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
eISSN - 2231-4040
pISSN - 0976-2094
DOI - 10.4103/japtr.japtr_153_19
Subject(s) - wound healing , dermis , wound closure , biomedical engineering , micelle , chemistry , materials science , surgery , medicine , anatomy , aqueous solution
Self-assembly is an unparalleled step in designing macromolecular analogs of nature's simple amphiphiles. Tailoring hydrogel systems - a material with ample potential for wound healing applications - to simultaneously alleviate infection and prompt wound closure is vastly appealing. The poly (DEAEMA-co-AAc) (PDEA) is examined with a cutaneous excisional wound model alterations in wound size, and histological assessments revealed a higher wound healing rate, including dermis proliferation, re-epithelialization, reduced scar formation, and anti-inflammatory properties. Moreover, a mechanism for the formation of spherical and worm-like micelles (WLMs) is delineated using a suite of characterizations. The excellent porosity and ability to absorb exudates impart the PDEA with reliable wound healing. Altogether, this system demonstrates exceptional promise as an infection-mitigating, cell-stimulating, homeostasis-maintaining dressing for accelerated wound healing. The aim and objective of this study is to understand the mechanism of self-assembly in synthesized WLMs from PDEA and their application in wound healing.