Open AccessAntibiofilm effect of C-10 massoia lactone toward polymicrobial oral biofilms
Author(s) -
Diyah Utami,
Sylvia Utami Tunjung Pratiwi,
Herman P. Spaink,
Tetiana Haniastuti,
Triana Hertiani
Publication year - 2021
Publication title -
journal of advanced pharmaceutical technology and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
eISSN - 2231-4040
pISSN - 0976-2094
DOI - 10.4103/japtr.japtr_105_20
Subject(s) - biofilm , streptococcus mutans , microbiology and biotechnology , lactobacillus acidophilus , lactone , streptococcus sanguinis , chemistry , crystal violet , bacteria , biology , probiotic , stereochemistry , genetics
This study is aimed to test the efficacy of C-10 Massoia lactone in oral polymicrobial degradation. Polymicrobial of Streptococcus sanguinis , Streptococcus mutans , Lactobacillus acidophilus , and Actinomyces viscosus were studied. C-10 Massoia lactone against biofilm degradation was investigated using modified crystal violet for biofilm staining. The effectiveness of C-10 Massoia lactone against biofilms was calculated by the minimum biofilm inhibitory concentration (MBIC 50 ) and the minimum value of biofilm eradication concentration (MBEC 50 ). Scanning electron microscope was used to study biofilm cell viability and morphological changes. The results showed a degradation effect of C-10 Massoia lactone against mature oral polymicrobial at 0.25% v/v. C-10 Massoia lactone can degrade polymicrobial biofilms of S. mutans , S. sanguinis , L. acidophilus and A. viscosus . This compound can destroy the extracellular polymeric substances (EPS) of polymicrobial biofilms. The potential application of C-10 Massoia lactone for anti-polymicrobial medication should be applied in such a way that any negative effects are minimized. Further research is needed to confirm the findings of this study.