Open AccessLinezolid-induced serotonin syndrome
Author(s) -
Anish Shouan,
Rajeet Kumar,
Vivek Lal,
Sandeep Grover
Publication year - 2020
Publication title -
industrial psychiatry journal/industrial psychiatry journal
Language(s) - Uncategorized
Resource type - Journals
eISSN - 0976-2795
pISSN - 0972-6748
DOI - 10.4103/ipj.ipj_37_19
Subject(s) - linezolid , serotonin syndrome , cyproheptadine , serotonin , monoamine oxidase , medicine , monoamine oxidase inhibitor , pharmacology , staphylococcus aureus , chemistry , biology , bacteria , biochemistry , serotonergic , vancomycin , enzyme , receptor , genetics
Linezolid is an oxazolidinone antibiotic, which is a weak, reversible, nonselective monoamine oxidase A and B inhibitor; is known to increase serotonin levels, and has been implicated in the development of serotonin syndrome (SS). There is limited literature on the development of SS with linezolid, when used alone. In this report, we present the case of a 70-year-old female who developed features of SS while being treated with linezolid 600 mg twice daily for pneumonia. The SS in her case was managed with stoppage of linezolid, administration of cyproheptadine, and supportive measures.