Open AccessDevelopment of pityriasis amiantacea after valproic acid therapy
Author(s) -
Julio A. Díaz-Pérez,
Joel C. Joyce,
Thomas Cibull,
Thomas A. Victor
Publication year - 2018
Publication title -
international journal of trichology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 22
eISSN - 0974-9241
pISSN - 0974-7753
DOI - 10.4103/ijt.ijt_53_18
Subject(s) - valproic acid , gsk 3 , wnt signaling pathway , medicine , pharmacology , cancer research , biology , kinase , epilepsy , biochemistry , signal transduction , psychiatry
Here, we present the case of a 16-year-old male who developed pityriasis amiantacea (PA) after the use of valproic acid. We propose that the keratinocyte proliferative activity of valproic acid mediated through the inhibition of glycogen synthase kinase-3β, and subsequent activation of the Wnt/β-catenin pathway could play a role in the development of PA. We additionally review the most relevant characteristics of this disease.