Open AccessValue of CD123 immunohistochemistry and elastic staining in differentiating discoid lupus erythematosus from lichen planopilaris
Author(s) -
Fatemeh Sari Aslani,
Mozhdeh Sepaskhah,
Zahra Bagheri,
Mojgan AkbarzadehJahromi
Publication year - 2020
Publication title -
international journal of trichology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 22
eISSN - 0974-9241
pISSN - 0974-7753
DOI - 10.4103/ijt.ijt_32_20
Subject(s) - discoid lupus erythematosus , pathology , medicine , staining , dermis , immunohistochemistry , scarring alopecia , biopsy , differential diagnosis , infiltration (hvac) , lupus erythematosus , scalp , dermatology , antibody , immunology , physics , thermodynamics
Differentiating scarring alopecia secondary to lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) has always been a challenge clinically and pathologically. Plasmacytoid dendritic cells (PDCs) have been reported in the cutaneous lupus erythematosus by CD123 immunostaining. This study assesses CD123 marker positivity and patterns of elastic fiber loss in scalp biopsy to differentiate DLE from LLP.