Open AccessMinoxidil downregulates Interleukin-1 alpha gene expression in HaCaT cells
Author(s) -
Erkin Pekmezci,
Murat Türkoğlu,
Hilal Gökalp,
Zekayі Kutlubay
Publication year - 2018
Publication title -
international journal of trichology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 22
eISSN - 0974-9241
pISSN - 0974-7753
DOI - 10.4103/ijt.ijt_18_17
Subject(s) - hacat , minoxidil , pharmacology , glyceraldehyde 3 phosphate dehydrogenase , gene expression , cell growth , downregulation and upregulation , mechanism of action , keratinocyte , chemistry , microbiology and biotechnology , biology , medicine , in vitro , biochemistry , gene
Minoxidil has been used topically to stimulate hair growth for male androgenetic alopecia (AGA) for more than 3 decades. It is currently being used for female AGA and alopecia areata (AA) as well. Although much time has passed since its first use, our understanding of its mechanism of action is highly limited. Therefore, we examined the inflammatory properties of AGA and AA, two entities in which minoxidil is being used as a therapeutic agent. We investigated the in vitro expression levels of cytokine interleukin-1 alpha (IL-1α), a potent inhibitor of hair growth, in minoxidil-treated human keratinocyte (HaCaT) cells to determine whether this molecule exerts anti-inflammatory effects.