Open AccessMetabolic acidosis and encephalopathy in an HIV-exposed infant on breastfeeding and maternal antiretroviral therapy
Author(s) -
Ira Shah,
Jagdish Kathwate
Publication year - 2020
Publication title -
indian journal of sexually transmitted diseases and aids
Language(s) - English
Resource type - Journals
eISSN - 2589-0565
pISSN - 2589-0557
DOI - 10.4103/ijstd.ijstd_83_16
Subject(s) - medicine , breastfeeding , lactic acidosis , zidovudine , encephalopathy , metabolic acidosis , pediatrics , pregnancy , acidosis , adverse effect , antiretroviral therapy , human immunodeficiency virus (hiv) , obstetrics , immunology , viral load , viral disease , biology , genetics
Zidovudine (AZT) treatment during pregnancy, delivery, and the postnatal period is associated with adverse effects in the neonate such as bone marrow suppression, elevation in aspartate aminotransferase activity, and lactic acidosis. With antiretroviral therapy (ART) now being recommended for life in HIV-infected pregnant women, infants born to these mothers and on breastfeeds are going to be exposed to antiretrovirals for a longer duration. We report a rare case of an HIV-exposed infant who received AZT prophylaxis for 6 weeks after birth and was on exclusive breastfeed while the mother was on ART and presented with unexplained severe metabolic acidosis and encephalopathy.