Open AccessAlteration in the number and integrity of white matter tracts in the preterm: A quantitative diffusion tensor imaging and diffusion fibre tractography in children
Author(s) -
Ruma Madhu Sreedharan,
Subramonium Aiyappan,
Nina Roy
Publication year - 2017
Publication title -
indian journal of radiology and imaging - new series/indian journal of radiology and imaging/indian journal of radiology and imaging
Language(s) - English
Resource type - Journals
eISSN - 0971-3026
pISSN - 0970-2016
DOI - 10.4103/ijri.ijri_494_15
Subject(s) - diffusion mri , white matter , medicine , periventricular leukomalacia , corpus callosum , fractional anisotropy , hypoxia (environmental) , magnetic resonance imaging , tractography , pathology , nuclear medicine , cardiology , gestational age , radiology , pregnancy , chemistry , biology , genetics , organic chemistry , oxygen
Periventricular white matter is most commonly injured in preterm babies with hypoxia. To assess white matter damage, we decided to perform diffusion tensor imaging (DTI) in preterm children with history of hypoxia and magnetic resonance imaging (MRI) features of periventricular leukomalacia (PVL) (PTH). We hypothesized that the PTH have reduced number of white matter fibres compared to age matched pre term children without hypoxia (PTHO), and also depending on the severity of PVL, there could be reduction in the number of fibres as well.