Open AccessDual-color dual-hapten in situ hybridization (D-DISH) – Comparison with fluorescence in situ hybridization (FISH) for HER2/neu testing in breast cancer
Author(s) -
Pooja Kamlesh Gajaria,
Sonali Tambe,
Trupti Pai,
Asawari Patil,
Sangeeta Desai,
Tanuja Shet
Publication year - 2020
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_861_19
Subject(s) - concordance , fluorescence in situ hybridization , breast cancer , in situ hybridization , trastuzumab , her2/neu , pathology , kappa , fish <actinopterygii> , microbiology and biotechnology , cancer , medicine , biology , mathematics , chromosome , genetics , gene expression , geometry , fishery , gene
HER2/neu testing in breast cancer is a mandate due to availability of trastuzumab, a monoclonal antibody targeted against this biomarker. Dual-color dual-hapten in situ hybridization (D-DISH) is a new test for assessment of HER2/neu gene overexpression on light microscopy.