Open AccessLimited granulomatosis with polyangiitis presenting as an isolated lung lesion
Author(s) -
Shameera Begum,
Sowmya Subramanian,
K Shanmugasamy,
Anandraj Vaithy
Publication year - 2020
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_831_19
Subject(s) - medicine , granulomatosis with polyangiitis , pathology , necrotizing vasculitis , lung , vasculitis , anti neutrophil cytoplasmic antibody , sarcoidosis , biopsy , microscopic polyangiitis , lung biopsy , systemic vasculitis , lesion , respiratory system , systemic disease , disease
Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis involving small and medium-sized blood vessels and granulomatous inflammation of upper and lower respiratory systems and/or renal system. In the limited form of GPA, there is no systemic involvement of disease with sparing of kidneys. The respiratory system is the commonly involved organ in limited GPA. Herein, we report the case of a 40-year-old male who was initially diagnosed as sarcoidosis clinically. Lung biopsy revealed necrotizing granulomatous angiitis. Diagnosis of GPA was made which was substantiated by antineutrophil cytoplasmic antibody (ANCA) positivity. This was a case of limited GPA with isolated lung involvement. The early diagnosis and initiation of treatment are critical for improved survival of patients with GPA. Tissue biopsy is necessary for the diagnosis of GPA.