Differential expression of cyclin E, p63, and Ki-67 in gestational trophoblastic disease and its role in diagnosis and management: A prospective case–control study | Zendy

Asaranti Kar | Zendy; Chandraprava Mishra | Zendy; Priyadarshini Biswal | Zendy; Tushar Kar | Zendy; Sasmita Panda | Zendy; Subhasini Naik | Zendy

Open Access

Differential expression of cyclin E, p63, and Ki-67 in gestational trophoblastic disease and its role in diagnosis and management: A prospective case–control study

Author(s) -

Asaranti Kar,

Chandraprava Mishra,

Priyadarshini Biswal,

Tushar Kar,

Sasmita Panda,

Subhasini Naik

Publication year - 2019

Publication title -

indian journal of pathology and microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 31

eISSN - 0974-5130

pISSN - 0377-4929

DOI - 10.4103/ijpm.ijpm_82_18

Subject(s) - immunohistochemistry , choriocarcinoma , gestational trophoblastic disease , placental site trophoblastic tumor , pathology , cell cycle , ki 67 , differential diagnosis , biology , cyclin e , andrology , placenta , cyclin a , cyclin , medicine , pregnancy , fetus , gestation , cancer , genetics

Gestational trophoblastic disease (GTD) constitutes a spectrum of tumors and tumor-like conditions, characterized by proliferation of pregnancy-associated trophoblastic tissue of progressive malignant potential. It is very difficult to differentiate these complex groups of lesions basing on histomorphology alone. Immunohistochemistry (IHC) with cyclin E, P63, and Ki-67 has a definite role in the identification of different trophoblasts and entities of GTD and also in the determination of biological behavior.

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