Open AccessDifferential expression of cyclin E, p63, and Ki-67 in gestational trophoblastic disease and its role in diagnosis and management: A prospective case–control study
Author(s) -
Asaranti Kar,
Chandraprava Mishra,
Priyadarshini Biswal,
Tushar Kar,
Sasmita Panda,
Naik Ss
Publication year - 2019
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_82_18
Subject(s) - choriocarcinoma , immunohistochemistry , placental site trophoblastic tumor , gestational trophoblastic disease , pathology , differential diagnosis , ki 67 , cell cycle , biology , staining , cyclin e , placenta , cyclin a , andrology , cyclin , medicine , pregnancy , fetus , gestation , cancer , genetics
Gestational trophoblastic disease (GTD) constitutes a spectrum of tumors and tumor-like conditions, characterized by proliferation of pregnancy-associated trophoblastic tissue of progressive malignant potential. It is very difficult to differentiate these complex groups of lesions basing on histomorphology alone. Immunohistochemistry (IHC) with cyclin E, P63, and Ki-67 has a definite role in the identification of different trophoblasts and entities of GTD and also in the determination of biological behavior.