Open AccessInvasive cutaneous mucormycosis in a preterm neonate presenting as a vesicobullous lesion
Author(s) -
S. K. Mishra,
Divya Shelly,
Divya Gupta,
Reena Bharadwaj
Publication year - 2018
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_796_16
Subject(s) - mucormycosis , medicine , lesion , mycosis , amphotericin b , periodic acid–schiff stain , dermatology , gestation , biopsy , pathology , surgery , antifungal , pregnancy , biology , staining , genetics
Mucormycosis is a relatively rare fungal infection seen in immunocompromised patients. Very few cases of invasive cutaneous mucormycosis occurring in neonates have been reported in literature. It is an aggressive disease with a mortality rate of around 64% in neonates, so a high index of suspicion is essential for rapid diagnosis and definitive treatment with broad-spectrum antifungals such as Amphotericin B. We present a case of a premature infant born at 25 weeks of gestation who developed vesicobullous lesions all over the body on day 5 of life. Biopsy from the vesicles confirmed the presence of angioinvasive fungal hyphae of mucormycosis which were highlighted on Periodic acid-Schiff and Grocott stain.