Open AccessStory of survival in anaplastic large cell lymphoma - sometimes more than the anaplastic lymphoma kinase status: An evaluation of pathologic prognostic factors in 102 cases
Author(s) -
Komal Agrawal,
Tanuja Shet,
Sridhar Epari,
Suhas Dhende,
Manju Sengar,
Brijesh Arora,
Siddhartha Laskar,
Sumeet Gujral,
Hari Me,
Shripad Banavali
Publication year - 2017
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_778_15
Subject(s) - anaplastic lymphoma kinase , anaplastic large cell lymphoma , medicine , lymphoma , pathological , oncology , univariate analysis , stage (stratigraphy) , b symptoms , pathology , survival analysis , survival rate , multivariate analysis , lung cancer , biology , paleontology , malignant pleural effusion
Systemic anaplastic large cell lymphoma (ALCL) accounts for 5%-10% of adult non Hodgkin's lymphoma (NHL) and 10%-30% of childhood NHL. Owing to significant differences in survival and gene expression profile, current WHO classifies ALCL into two distinct entities as anaplastic lymphoma receptor tyrosine kinase (ALK) positive and ALK negative ALCL with ALK expression by tumour as a good prognostic indicator. However, in our institute which is a cancer referral institute, our preliminary experience was that even ALK positive tumours did not fare well as compared to ALK- negative ALCL. So, the current study aims at exploring more clinical and pathological factors impacting survival in ALCL patients.