Open AccessKi-67 evaluation in breast cancer: The daily diagnostic practice
Author(s) -
Łukasz Fuławka,
Agnieszka Hałoń
Publication year - 2017
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_732_15
Subject(s) - kappa , breast cancer , medicine , rank correlation , ki 67 , youden's j statistic , spearman's rank correlation coefficient , cancer , malignancy , population , pathology , oncology , nuclear medicine , immunohistochemistry , receiver operating characteristic , mathematics , statistics , geometry , environmental health
Breast cancer is the most common malignancy in females. It is routinely classified according to the WHO histological typing. However, there is also a molecular classification of breast cancer which is routinely substituted with surrogate subtypes based on expression of estrogen, progesterone, and human epidermal growth factor receptor 2 receptors and proliferation index (PI). PI is defined as the percentage of Ki-67-positive cells among overall cell population. The method commonly applied by pathologists to determine PI is visual scoring of the sample. Strict recommendations for PI assessment do not exist. Thus, the mode of PI evaluation differs significantly between pathologists.