Open AccessMyeloid cell leukemia-1 protein expression and myeloid cell leukemia-1 gene amplification in non small cell lung cancer
Author(s) -
Tony El Jabbour,
Siddhartha Dalvi,
Sungeun Kim,
Christine Sheehan,
Jeffrey S. Ross
Publication year - 2018
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_731_16
Subject(s) - myeloid leukemia , runx1t1 , cancer research , leukemia , lung cancer , cell , myeloid , gene , biology , gene expression , medicine , immunology , oncology , genetics
Myeloid cell leukemia-1 (Mcl-1) is a member of the B-cell lymphoma 2 family known to play a significant role in the regulation of apoptosis. Mcl-1 expression has been studied in nonsmall cell lung cancer (NSCLC) cell lines but has not been previously evaluated as a prognostic factor in clinical samples.