Open AccessRole of ERCC1 expression in colorectal adenoma-carcinoma sequence and relation to other mismatch repair proteins expression, clinicopathological features and prognosis in mucinous and non-mucinous colorectal carcinoma
Author(s) -
Abd Al Rahman Mohammad Foda,
Andrea Palicelli,
Abdelhadi M. Shebl,
Renzo Boldorini,
Khaled Elnaghi,
Amira Kamal El-Hawary
Publication year - 2019
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_684_18
Subject(s) - ercc1 , msh6 , msh2 , pms2 , mucinous carcinoma , mlh1 , tissue microarray , colorectal adenoma , cancer research , medicine , immunohistochemistry , adenocarcinoma , dna mismatch repair , pathology , colorectal cancer , nucleotide excision repair , biology , dna repair , gene , cancer , genetics
There are several DNA repair pathways that protect cellular DNA from injury, such as nucleotide excision repair (NER) and mismatch repair (MMR). The protein product of the excision repair cross-complementation group 1 (ERCC1) gene plays a pivotal role in NER. The exact relationship between MMR proteins and ERCC1 is not well known in colorectal carcinoma (CRC).