Open AccessThe extent of cyclin D1 expression in endometrial pathologies and relevance of cyclin D1 with the clinicopathological features of endometrioid endometrial carcinoma
Author(s) -
Hülya Tosun Yıldırım,
Döndü Nergiz,
Canan Sadullahoğlu,
Zelal Akgündüz,
Şenay Yıldırım,
Selen Doğan,
Cem Sezer
Publication year - 2020
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_589_19
Subject(s) - cyclin d1 , carcinoma , immunohistochemistry , cancer research , lymphovascular invasion , medicine , oncology , pathology , cyclin , biology , cell cycle , cancer , metastasis
Cyclin D1, a member of the cyclin protein family, is instrumental in the cell cycle due to its influence on the progression from G1 to the S phase. Its overexpression causes reduced doubling time and is also associated with clonogenic growth. The purpose of the present study was to assess cyclin D1 expression in patients with simple hyperplasia (SH), endometrial intraepithelial neoplasia (EIN) and endometrioid endometrial carcinoma, and to evaluate whether there was an association between cyclin D1 expression and the clinicopathological features of endometrioid endometrial carcinoma.