Open AccessEvaluation of the presence of myofibroblasts and matrix metalloproteinase 1 expression in the stroma of oral verrucous hyperplasia and verrucous carcinoma
Author(s) -
Nazanin Mahdavi,
Pouyan Aminishakib,
Parisa Nabiyi,
Alireza Ghanadan,
Maedeh Ghorbanpour,
Merva Soluk Tekkeşın
Publication year - 2020
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_548_19
Subject(s) - verrucous carcinoma , immunohistochemistry , stromal cell , myofibroblast , pathology , stroma , medicine , matrix metalloproteinase , proliferation index , carcinoma , cancer research , oncology , fibrosis
Oral verrucous carcinoma is a low-grade subtype of oral squamous cell carcinoma that should be differentiated from oral verrucous hyperplasia, a premalignant lesion. Stromal activated myofibroblasts known as cancer-associated fibroblasts have an active role in the initiation and progression of the cancers via secretion of different molecules including matrix metalloproteinases.