Open AccessRecurrent DHA nephropathy in renal allograft—revisiting clinicopathological aspects of a rare entity
Author(s) -
Jyotsna Yesodharan,
N V Seethalekshmy,
Rajesh Nair
Publication year - 2021
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_441_20
Subject(s) - medicine , adenine phosphoribosyltransferase , nephropathy , renal function , pathology , biopsy , renal biopsy , rare disease , microscopic hematuria , kidney , allopurinol , disease , urology , purine , endocrinology , diabetes mellitus , proteinuria , enzyme , chemistry , biochemistry
Adenine phosphoribosyltransferase (APRT) enzyme deficiency is a rare autosomal recessive disorder of purine metabolism affecting mainly the kidneys. It can present at any age with varying degrees of acute and chronic renal damage. Though xanthine dehydrogenase inhibitors offer effective control over the disease process, delay in diagnosis and treatment often lead to compromised function of native and even graft kidneys.