Open AccessPrevalence estimation of microsatellite instability in colorectal cancers using tissue microarray based methods – A tertiary care center experience
Author(s) -
Sonali Susmita Nayak,
Paromita Roy,
Neeraj Arora,
Indu Arun,
Manas Kumar Roy,
Sudeep Banerjee,
Indranil Mallick,
Mohandas K. Mallath
Publication year - 2018
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_430_17
Subject(s) - msh6 , pms2 , microsatellite instability , mlh1 , msh2 , tissue microarray , univariate analysis , medicine , lynch syndrome , oncology , immunohistochemistry , pathology , multivariate analysis , colorectal cancer , biology , dna mismatch repair , cancer , microsatellite , genetics , allele , gene
Microsatellite instability (MSI) pathway is known to be implicated in carcinogenesis of 15% colorectal carcinomas (CRC), including 2%-3% of cases of Lynch syndrome, as per western literature. MSI status has important prognostic and therapeutic implications. The prevalence of MSI in Indian CRC patients is unknown. We aimed to determine the prevalence by studying 231 consecutive unselected cases of CRC.