Open AccessAssociation of different patterns of expression of beta-catenin and cyclin D1 with pathogenesis of breast carcinoma
Author(s) -
Kachnar Varma,
Aprajita Chauhan,
M Bhargava,
Vatsala Misra,
Sapan Srivastava
Publication year - 2020
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_419_19
Subject(s) - cyclin d1 , wnt signaling pathway , immunohistochemistry , cancer research , carcinogenesis , beta catenin , cancer , breast cancer , cyclin , catenin , carcinoma , medicine , biology , oncology , pathology , cell cycle , gene , genetics
Beta-catenin and cyclin D1 have attracted considerable attention in recent studies as potential proto-oncogenes in many human cancers especially colonic cancer. Beta-catenin plays multiple roles within the cell such as canonical Wnt signaling where cyclin D1 has been identified as one of its target genes. The role of beta-catenin and cyclin D1 in breast cancer has been evaluated in many studies but not established yet.