Open AccessAssessment of fragile histidine triad expression in ameloblastoma, odontogenic keratocyst and dentigerous cyst
Author(s) -
Vanishri C Haragannavar,
Anand S Tegginamani,
Shashidara Raju,
Shailesh Kudva,
Celestina Dawn Peter,
D K Shruthi
Publication year - 2019
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_403_18
Subject(s) - keratocyst , fhit , ameloblastoma , dentigerous cyst , pathology , cyst , biology , keratocystic odontogenic tumor , odontogenic tumor , medicine , odontogenic , tumor suppressor gene , anatomy , cancer , carcinogenesis , genetics , maxilla
FHIT (Fragile histidine triad) a member of tumor suppressor family, has been extensively studied in many solid tumors including head and neck squamous cell carcinoma. Among all head and neck cyst and tumors odontogenic lesions account approximately 3%-9%. The molecular pathogenesis of these lesions is less explored. Defects in cell cycle regulators and tumor suppressor genes could result in the development of odontogenic cyst and tumors. Hence, we aimed to determine the significant role of a tumor suppressor gene FHIT in most commonly occurring odontogenic lesions mainly ameloblastoma, odontogenic keratocyst and dentigerous cyst.