Open AccessSinonasal NUT midline carcinoma: A new histological entity
Author(s) -
Pragya Nirav Vakani,
Jainil Maheshwari,
Mukesh Maheshwari,
Bhoomi Shah
Publication year - 2020
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_373_19
Subject(s) - medicine , brd4 , immunohistochemistry , head and neck , carcinoma , nut , pathology , mediastinum , anatomy , surgery , gene , biology , structural engineering , engineering , acetylation , bromodomain , biochemistry
Nuclear protein in testis (NUT) midline carcinoma is poorly differentiated carcinoma defined by rearrangement of NUT gene on 15 to other genes, usually BRD4 on 19. It is first described in 1991. These tumors are most commonly seen in the mediastinum and 35% occur in head and neck. It is a highly aggressive tumor with a median survival of 7 months because of ineffective chemotherapy and undefined treatment. Hence, we must differentiate these tumors from other poorly differentiated tumors. Here, we present a case of NUT midline carcinoma of 44-year male, who presented with headache and dizziness, confirmed by immunohistochemistry of NUT antibody. The aim of this case report is to increase the awareness about this entity in adults with brief review of relevant literature.