Open AccessFibroblast growth factor receptor-1 associated myeloproliferative neoplasm and T-lymphoblastic lymphoma
Author(s) -
Gayathri Gopan,
T.M. Anoop,
NP Prakash,
Rakul Nambiar,
R Krishnachandran
Publication year - 2017
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_357_17
Subject(s) - lymphoblastic lymphoma , cancer research , myeloproliferative neoplasm , neoplasm , bcl10 , lymphoblastic leukemia , lymphoma , fibroblast growth factor , fibroblast growth factor receptor , medicine , receptor , biology , immunology , leukemia , pathology , bone marrow , t cell , myelofibrosis , immune system
Myeloid and lymphoid hematological malignancies with eosinophilia and abnormalities of fibroblast growth factor receptor-1 (FGFR1) result from the formation of abnormal fusion genes that encode constitutively activated tyrosine kinases. The WHO classification (2008) of hematolymphoid neoplasms recognizes a category of myeloid and lymphoid neoplasms with eosinophilia and abnormalities of FGFR1. Here, we present the case of a 30-year-old-woman who was diagnosed with T-lymphoblastic lymphoma from lymph node biopsy and myeloproliferative neoplasm with eosinophilia from bone marrow studies. She was treated with combination chemotherapy with cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD regimen) and is on maintenance chemotherapy for the past 2 months. We present this case to create awareness among physicians about this rare condition associated with dual malignancies.