Open AccessIncidentally detected asymptomatic hepatitis C virus infection with significant fibrosis: Possible impacts on management
Author(s) -
Rakesh Kumar Gupta,
Puja Sakhuja,
Kaushik Majumdar,
Shahajad Ali,
Siddharth Srivastava,
Sanjeev Sachdeva,
Barjesh C. Sharma,
Amarender Singh Puri
Publication year - 2018
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_240_17
Subject(s) - stage (stratigraphy) , asymptomatic , medicine , liver biopsy , gastroenterology , alanine transaminase , hepatocellular carcinoma , fibrosis , hepatitis c virus , biopsy , liver disease , hepatitis c , aspartate transaminase , titer , pathology , immunology , virus , biology , paleontology , biochemistry , alkaline phosphatase , enzyme
Liver biopsy may be considered in patients with hepatitis C virus (HCV) infection to assess the severity of liver injury and stage of fibrosis, thereby guiding therapeutic decisions. In addition, advanced stage also necessitates surveillance for hepatocellular carcinoma. The aim of this study was to assess whether transaminase (alanine transaminase [ALT]) levels and RNA titers correlate with the histological activity index (HAI) and fibrosis (F) stage in asymptomatic patients with incidentally detected HCV (IDHCV).