Open AccessPrimary signet cell adenocarcinoma of bladder
Author(s) -
Prateek Kinra,
S Rashmi,
Aftab Alam,
Harkirat Singh,
Shaswat Dash
Publication year - 2017
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_201_16
Subject(s) - urothelium , signet ring cell , pathology , adenocarcinoma , urinary bladder , signet ring cell carcinoma , mucin , medicine , stomach , bladder cancer , epithelium , histogenesis , cancer , immunohistochemistry
Primary signet cell cancer of the urinary bladder is a relatively rare entity. Since there is no mucinous epithelium in the bladder, It is proposed that the tumor arises from metaplastic urothelium. Two thirds of the tumours are mucin secreting, in most of which the site of the deposition is either extracellular or intracellular displacing the nucleus to a peripheral crescent, giving the cells a signet ring appearance. The tumours are most often infiltrative and diffusely involving the majority of the bladder akin to its name sake in stomach. It is essential to distinguish this carcinoma from gastrointestinal metastases as different therapeutic strategies are often necessary.