Open AccessManagement of transfusion needs in a case of immunizing anti-M antibody in a patient with acute myeloid leukemia
Author(s) -
Anisha Navkudkar,
P. B. Desai,
Rajesh Thakkar,
Sunil Rajadhyaksha
Publication year - 2020
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_166_19
Subject(s) - antibody , abo blood group system , medicine , immunology , isoantibodies , antigen , myeloid leukemia , leukemia , coombs test
Anti-M is a relatively common "naturally occurring" antibody. Unexpected alloantibodies in patient's serum other than ABO isoagglutinins (e.g., anti-M) may cause a discrepancy in the reverse grouping. As long as anti-M does not react at 37°C, it is clinically insignificant for transfusion. However, we found this antibody to be of "immunizing" type which was reactive at 37°C and AHG phase and showing problems in blood grouping and crossmatch. This antibody had both IgM and IgG components. When "M" antibodies active at 37°C are encountered, antigen-negative or red cells that are compatible with an indirect antiglobulin test should be provided.