Open AccessInterobserver reproducibility of tumor-infiltrating lymphocyte evaluations in breast cancer
Author(s) -
Fatmagül Çabuk,
Fatma Aktepe,
Fatma Nilgün Kapucuoğlu,
İpek Çoban,
Dauren Sarsenov,
Vahit Özmen
Publication year - 2018
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/ijpm.ijpm_131_17
Subject(s) - medicine , breast cancer , tumor infiltrating lymphocytes , reproducibility , triple negative , nuclear medicine , h&e stain , pathology , triple negative breast cancer , confidence interval , cancer , oncology , immunohistochemistry , statistics , mathematics , immunotherapy
Tumor-infiltrating lymphocytes (TILs) have a prognostic value in breast cancer (BC); however, because of the lack of standard evaluation methods, we aimed to assess the interobserver agreement of stromal TILs (sTILs) and intratumoral TILs (iTILs) as well as the effect of hot spot areas and molecular subtyping on the overall agreement.