Open AccessEffect of diethyldithiocarbamate in cyclophosphamide-induced nephrotoxicity: Immunohistochemical study of superoxide dismutase 1 in rat
Author(s) -
Vaibhav G Sheth,
Umashanker Navik,
Krishna P. Maremanda,
Gopabandhu Jena
Publication year - 2018
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_850_16
Subject(s) - nephrotoxicity , superoxide dismutase , chemistry , pharmacology , in vivo , nitric oxide synthase , kidney , dismutase , cyclophosphamide , saline , toxicity , oxidative stress , biochemistry , medicine , enzyme , biology , chemotherapy , microbiology and biotechnology , organic chemistry
To investigate the role of diethyldithiocarbamate (DEDTC) in cyclophosphamide (CP)-induced nephrotoxicity in Sprague-Dawley rat. DEDTC is a known chelating agent for copper and zinc. It is also used as a thiol protecting agent, as nuclear factor kappa-light-chain-enhancer of activated B-cells inhibitor and nitric oxide synthase inhibitor. It is also reported to inhibit superoxide dismutase (SOD) both in vitro and in vivo conditions. Considering this wide range of actions, current study investigated the role of DEDTC in CP-induced nephrotoxicity in experimental rat model.