Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis | Zendy

SandraJerkovic Gulin | Zendy; Piotr Brzeziński | Zendy; Dario Gulin | Zendy; Anca Chiriac | Zendy

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Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis

Author(s) -

SandraJerkovic Gulin,

Piotr Brzeziński,

Dario Gulin,

Anca Chiriac

Publication year - 2017

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/ijp.ijp_838_16

Subject(s) - metrorrhagia , itraconazole , drug , medicine , dermatology , estrogen , pharmacology , antifungal , family planning , population , research methodology , environmental health

We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.

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