Open AccessIatrogenic metrorrhagia after the use of itraconazole for onychomycosis
Author(s) -
Piotr Brzeziński,
Sandra Jerković Gulin,
Dario Gulin,
Anca Chiriac
Publication year - 2017
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_838_16
Subject(s) - metrorrhagia , itraconazole , drug , medicine , dermatology , estrogen , pharmacology , antifungal , family planning , population , research methodology , environmental health
We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.