Open AccessSafety and efficacy of riboflavin-assisted collagen cross-linking of cornea in progressive keratoconus patients: A prospective study in North East India
Author(s) -
Anusuya Bhattacharyya,
Phulen Sarma,
Kalyan Kumar Das,
Balmukund Agarwal,
Jnanankar Medhi,
Shyam Sundar Das Mohapatra
Publication year - 2019
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_75_19
Subject(s) - keratoconus , keratometer , riboflavin , ophthalmology , medicine , corneal collagen cross linking , cornea , population , visual acuity , chemistry , biochemistry , environmental health
Riboflavin- and ultraviolet (UV)-A-mediated collagen cross-linking of the cornea is a frequently used therapeutic measure for the treatment of progressive keratoconus (PK). First, riboflavin increases cross-linking and second, it serves as a protective shield to other deep ocular structures. However, pharmacogenomic variation in riboflavin efficacy is reported. As the Northeast Indian population represents a genetically diverse group of population compared to mainstream India, we have assessed the efficacy of the procedure in a northeastern population with PK.