Open AccessCo-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate
Author(s) -
Meenu Dutt,
Ravinder Naik Dharavath,
Tarundeep Kaur,
Navpreet Kaur,
Kanwaljit Chopra,
Shweta Sharma
Publication year - 2020
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_758_19
Subject(s) - alprazolam , medicine , creatinine , adverse effect , nephrotoxicity , methylphenidate , alkaline phosphatase , renal function , oxidative stress , kidney , physiology , pharmacology , endocrinology , anxiety , psychiatry , chemistry , attention deficit hyperactivity disorder , biochemistry , enzyme
Methylphenidate (MPH) is a first-line treatment option for attention-deficit hyperactive disorder and narcolepsy. MPH is one of the most abused psychostimulants by the adults and young population to stay awake, perform better, or improve concentration. The scanty reports say that the medical users or abusers mostly consider the administration of benzodiazepines to overcome the adverse effects, i.e., mood- and anxiety-related problems associated with MPH chronic abuse. This work aims to study the effect of alprazolam (ALZ) on MPH-associated adverse effects on liver and kidney.