Open AccessThe impact of antidepressant treatment on brain-derived neurotrophic factor level: An evidence-based approach through systematic review and meta-analysis
Author(s) -
Vijayakumar Arumugam,
Vini Susan John,
Nisha Augustine,
Taniya Jacob,
Sagar Maliakkal Joy,
Suchandra Sen,
Tuhinadri Sen
Publication year - 2017
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_700_16
Subject(s) - antidepressant , meta analysis , brain derived neurotrophic factor , medicine , confidence interval , publication bias , oncology , rating scale , neurotrophic factors , strictly standardized mean difference , biomarker , inclusion and exclusion criteria , depression (economics) , psychology , psychiatry , chemistry , pathology , developmental psychology , biochemistry , receptor , alternative medicine , macroeconomics , hippocampus , economics
Antidepressant treatment alters brain-derived neurotrophic factor (BDNF) levels, but it is not well established whether BDNF can be used as a marker to prove the efficacy of antidepressant treatment. The present systematic review and meta-analysis aim at assessing the influence of antidepressant treatment on BDNF level and the Hamilton Depression Rating Scale (HDRS) score, thereby to establish the rationale of utilizing BDNF as a predictive biomarker and HDRS score as an indicator for antidepressant treatment efficacy.