Open AccessIn vivo anticlastogenic effect of silymarin from milk thistle Silybum marianum L.
Author(s) -
Sirajudheen Anwar,
Hafez Madkor,
Nafees Ahemad,
Mohamed Wagih
Publication year - 2018
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_660_16
Subject(s) - silybum marianum , milk thistle , genotoxicity , in vivo , bone marrow , pharmacology , silibinin , chemistry , traditional medicine , biology , medicine , immunology , toxicity , microbiology and biotechnology , organic chemistry
Silymarin, extracted from the seeds of Silybum marianum L. (Milk thistle), is traditionally used for treating various illnesses such as diabetes, cancer, inflammation, hepatitis, liver cirrhosis, and renal problems. Acute cytotoxicity and genotoxicity studies have been reported with ambiguous outcomes; however, its relevant anticlastogenic potential is not yet evaluated. This study was aimed to evaluate in vivo subacute anticlastogenic properties of silymarin to validate its use as a medicinal agent.