In vivo anticlastogenic effect of silymarin from milk thistle Silybum marianum L. | Zendy

Sirajudheen Anwar | Zendy; HafezR Madkor | Zendy; Nafees Ahmed | Zendy; MohamedE Wagih | Zendy

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In vivo anticlastogenic effect of silymarin from milk thistle Silybum marianum L.

Author(s) -

Sirajudheen Anwar,

HafezR Madkor,

Nafees Ahmed,

MohamedE Wagih

Publication year - 2018

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/ijp.ijp_660_16

Subject(s) - silybum marianum , milk thistle , genotoxicity , in vivo , bone marrow , pharmacology , silibinin , chemistry , traditional medicine , biology , medicine , immunology , toxicity , microbiology and biotechnology , organic chemistry

Silymarin, extracted from the seeds of Silybum marianum L. (Milk thistle), is traditionally used for treating various illnesses such as diabetes, cancer, inflammation, hepatitis, liver cirrhosis, and renal problems. Acute cytotoxicity and genotoxicity studies have been reported with ambiguous outcomes; however, its relevant anticlastogenic potential is not yet evaluated. This study was aimed to evaluate in vivo subacute anticlastogenic properties of silymarin to validate its use as a medicinal agent.

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