Open AccessHuman adipose-derived stem cells reduce receptor-interacting protein 1, receptor-interacting protein 3, and mixed lineage kinase domain-like pseudokinase as necroptotic markers in rat model of Alzheimer’s disease
Author(s) -
Mina Eftekharzadeh,
Sara Simorgh,
Maryam Doshmanziari,
Leila Hassanzadeh,
Marjan Shariatpanahi
Publication year - 2020
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_545_19
Subject(s) - biology , stem cell , necroptosis , adipose tissue , receptor , microbiology and biotechnology , pathology , programmed cell death , endocrinology , biochemistry , medicine , apoptosis
Alzheimer's disease (AD) is a constant, developing brain impairment that is described as the aggregation of misfolded amyloid-beta-peptide (Ab) and abnormal tau protein in the brain. Stem cell therapy became a favorable candidate for the regeneration of neurodegenerative disorders like AD, but there is still shortage of knowledge about the underlying mechanisms. The goal of this survey was the determination of the necroptotic pathway as the possible mechanism for the effect of human adipose-derived stem cells (hADSCs) in the rat model of AD.