Open AccessTopiramate-induced acute liver injury: A rare adverse effect
Author(s) -
Archish Khivsara,
Jeffrey Pradeep Raj,
Divya Hegde,
Mangala Rao
Publication year - 2017
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_414_16
Subject(s) - topiramate , medicine , carbamazepine , valproic acid , adverse effect , somnolence , liver injury , drug , anesthesia , asymptomatic , pharmacology , epilepsy , psychiatry
Idiosyncratic drug-induced liver injury (DILI) is damage to liver occurring at recommended dose of a drug in contrast to toxic or predictable DILI. Although it is common in first-generation antiepileptic drugs (AEDs), it is rare in newer AEDs such as topiramate. Topiramate commonly causes neurological adverse effects such as psychomotor slowing and somnolence. Hepatotoxicity by topiramate is rare and has been previously reported in combination with other drugs such as valproate and carbamazepine. Here, we report a case of topiramate-induced asymptomatic elevation of liver enzymes in an adult man diagnosed with alcohol dependence syndrome and alcohol withdrawal complicated with seizures.