Open AccessIn silico approach to study the metabolism and biological activities of oligomeric proanthocyanidin complexes
Author(s) -
Sankar Jamuna,
Rathinavel Ashokkumar,
Sakeena Sadullah Mohammed Sadullah,
S. Niranjali Devaraj
Publication year - 2018
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_36_17
Subject(s) - in silico , metabolism , chemistry , antioxidant , cytochrome p450 , pharmacology , drug metabolism , toxicity , biochemistry , redox , biological activity , biology , in vitro , organic chemistry , gene
Over the past three decades, numerous studies have focused on the biological activities of oligomeric proanthocyanidins (OPCs) in the prevention of many diseases such as neurodegeneration, atherosclerosis, tumorigenesis, and microbial infections. OPC has redox-active metabolites which could modulate the intracellular redox equilibrium to maintain the antioxidant homeostasis. This redox-modulating efficiency of OPC could provide new insights into therapeutic approaches that could reduce the burden of cardiovascular diseases. The main objective of this study was to explore the biological and metabolic activities of OPC using in silico approaches.