Efficacy ratio: A tool to enhance optimal antimicrobial use for intra-abdominal infections | Zendy

Balaji Veeraraghavan | Zendy; P. Sabu | Zendy; Divyaa Elangovan | Zendy; AgilaKumari Pragasam | Zendy; YamunaDevi Bakthavatchalam | Zendy; Camilla Rodrigues | Zendy; DS Chitnis | Zendy; BhaskarNarayan Chaudhuri | Zendy

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Efficacy ratio: A tool to enhance optimal antimicrobial use for intra-abdominal infections

Author(s) -

Balaji Veeraraghavan,

P. Sabu,

Divyaa Elangovan,

AgilaKumari Pragasam,

YamunaDevi Bakthavatchalam,

Camilla Rodrigues,

DS Chitnis,

BhaskarNarayan Chaudhuri

Publication year - 2018

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/ijp.ijp_264_18

Subject(s) - ertapenem , tazobactam , piperacillin , antimicrobial , amikacin , antibiotics , antibiotic resistance , klebsiella pneumoniae , minimum inhibitory concentration , medicine , cefotetan , microbiology and biotechnology , meropenem , biology , escherichia coli , imipenem , bacteria , pseudomonas aeruginosa , gene , biochemistry , genetics

Antimicrobial resistance and inappropriate antibiotic regimen hamper a favorable outcome in intra-abdominal infections. Clinicians rely on the minimum inhibitory concentration (MIC) value to choose from the susceptible antimicrobials. However, the MIC values cannot be directly compared between the different antibiotics because their breakpoints are different. For that reason, efficacy ratio (ER), a ratio of susceptible MIC breakpoint and MIC of isolate, can be used to choose the most appropriate antimicrobial.

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